Not every patient needs triglyceride check, but all can get pancreatitis: A systematic review and clinical characterization of Isotretinoin associated Pancreatitis

Abstract

Isotretinoin is a medication to treat primarily nodulocystic acne vulgaris. A serious complication is pancreatitis, either idiosyncratic, and not preventable or predictable; or due to elevated triglycerides. Triglyceride are elevated in practically all patients on isotretinoin, but may not be abnormal, or too minimally elevated to pose a pancreatitis risk.¹ Elevated triglycerides are not a cause of arteriosclerotic risk. but can be a marker.^2,3 Objective of this review was to clinically characterize patients with isotretinoin induced pancreatitis particularly due to hypertriglyceridemia to evaluate what monitoring is sensible.

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