Complication and surgical site infection for salvage surgery in head and neck cancer after chemoradiotherapy and bioradiotherapy

Publication date: Available online 30 December 2016
Source:Auris Nasus Larynx
Author(s): Hidenori Suzuki, Nobuhiro Hanai, Daisuke Nishikawa, Yujiro Fukuda, Yasuhisa Hasegawa
ObjectiveWe aimed to investigate the complications, surgical site infection (SSI), and survival in salvage surgery without free-flap reconstruction for patients with head and neck squamous cell carcinoma who were treated by platinum-based chemoradiotherapy (Plat-CRT) or cetuximab-based bioradiotherapy (Cet-BRT).MethodsThirty-three patients treated by Plat-CRT and six treated by Cet-BRT had salvage surgery. We categorized postoperative complications according to the Clavien–Dindo classification and SSI according to the wound grading scale. Overall survival calculated by Kaplan–Meier method.ResultsPatients with Cet-BRT were significantly associated with the presence of SSI (P<0.01) and grades IIIb–V of the Clavien–Dindo classification (P<0.01) compared with those with Plat-CRT. Patients with Cet-BRT had a significantly lower overall survival than those with Plat-CRT (P<0.05).ConclusionWe demonstrated that patients with Cet-BRT were significantly more associated with the presence of SSI and grades IIIb–V in the Clavien–Dindo classification than those with CRT.



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