Interleukin-6 in the Cerebrospinal Fluid as Biomarker for Onset of Vasospasm and Ventriculitis after Severe Subarachnoidal Hemorrhage.

Related Articles

Interleukin-6 in the Cerebrospinal Fluid as Biomarker for Onset of Vasospasm and Ventriculitis after Severe Subarachnoidal Hemorrhage.

World Neurosurg. 2016 Dec 05;:

Authors: Lenski M, Huge V, Briegel J, Tonn JC, Schichor C, Thon N

Abstract
OBJECTIVE: Study aim was to investigate the diagnostic potential of Interleukin-6(IL-6) and other soluble biomarkers in serum and cerebrospinal fluid(CSF) for early diagnosis of cerebral vasospasm (cVSSAH) and external ventricular drainage (EVD) associated ventriculitis (VCSAH) and to separate these conditions from aneurysmal subarachnoidal hemorrhage (aSAH) without further complication (SAH(w/o/c)).
METHODS: The concentrations of serum biomarkers and markers in the CSF were collected in 63 consecutive patients with aSAH and EVD. Arithmetical means and standard deviations (SD), area-under-the-curve (AUC), cutoff-values (C-OFF), sensitivity (SE) and specificity (SP) were calculated for markers and their correlation with SAH(w/o/c), cVSSAH and VCSAH.
RESULTS: Clinical courses included 27 patients with cVSSAH, 17 with VCSAH and 19 with SAH(w/o/c). Mean±SD CSFIL-6 values were 7588± 4580pg/ml at onset of VCSAH and 4102± 4970pg/ml for cVSSAH and higher than 234± 239pg/ml in SAH(w/o/c) (p<0.001). CSFIL-6 showed excellent diagnostic potential for differing between VCSAH and SAH(w/o/c) (AUC=1.00,C-OFF=707,SE=100%,SP=100%), and a moderate diagnostic potential for differing VCSAH from cVSSAH (AUC=0.757,C-OFF=3100pg/ml,SE=86.7%,SP=70.6%). The concentration of CSFIL-6 within the cVSSAH group was significantly increased compared to SAH(w/o/c) (AUC=0.937,C-OFF=530pg/ml,SE=87.5%,SP=91.7%).
CONCLUSIONS: CSFIL-6 is increased after aSAH in patients with cVSSAH or VCSAH. Patients with a CSFIL-6 above a cut-off value of 3100pg/ml have an increased likelihood for VCSAH; patients with CSFIL-6 levels between 530 and 3100pg/ml have an increased post-test probability for cVSSAH.

PMID: 27931942 [PubMed - as supplied by publisher]

http://ift.tt/2hfO4If