miR-708/LSD1 axis regulates the proliferation and invasion of breast cancer cells.

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miR-708/LSD1 axis regulates the proliferation and invasion of breast cancer cells.

Cancer Med. 2016 Apr;5(4):684-92

Authors: Ma L, Ma S, Zhao G, Yang L, Zhang P, Yi Q, Cheng S

Abstract
Breast cancer is one of the most common malignant tumors in women worldwide. The microRNAs (miRNAs) are small, noncoding RNAs that regulate various biological processes, including breast cancer. miR-708 played an important role in a variety of cancers. However, its involvement in breast cancer remains largely unclear. In this study, we found that forced the expression of miR-708 in breast cancer cell lines decreased cell proliferation and invasion, whereas inhibition of miR-708 increased cell growth and invasion. miR-708 could directly target the LSD1 3'UTR to downregulate the expression. Further studies suggested that inhibition of LSD1 could phenocopied function of the miR-708 overexpression in MDA-MB-231 cells .Overexpression of LSD1 could counteract the effects of miR-708 on the proliferation and invasion. Taken together, the results indicate that miR-708 may function as a tumor suppressor gene in breast cancer development, and miR-708/LSD1 axis may be a therapeutic intervention in breast cancer in the future.

PMID: 26833707 [PubMed - indexed for MEDLINE]

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