Poly (lactic acid)-based biomaterials for orthopaedic regenerative engineering

Publication date: 15 December 2016
Source:Advanced Drug Delivery Reviews, Volume 107
Author(s): Ganesh Narayanan, Varadraj N. Vernekar, Emmanuel L. Kuyinu, Cato T. Laurencin
Regenerative engineering converges tissue engineering, advanced materials science, stem cell science, and developmental biology to regenerate complex tissues such as whole limbs. Regenerative engineering scaffolds provide mechanical support and nanoscale control over architecture, topography, and biochemical cues to influence cellular outcome. In this regard, poly (lactic acid) (PLA)-based biomaterials may be considered as a gold standard for many orthopaedic regenerative engineering applications because of their versatility in fabrication, biodegradability, and compatibility with biomolecules and cells. Here we discuss recent developments in PLA-based biomaterials with respect to processability and current applications in the clinical and research settings for bone, ligament, meniscus, and cartilage regeneration.

Graphical abstract

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