Preclinical models in HNSCC: A comprehensive review

Head and neck squamous cell carcinoma (HNSCC) is the sixth most common type of cancer worldwide and remains a significant public health concern with an estimated 500,000 new cases diagnosed yearly. Over 90% of head and neck cancers are squamous cell carcinomas and arise in the upper aerodigestive tract, including the oral cavity, pharynx and larynx [1]. Five year survival is only 40% despite current therapeutic strategies including radiation, surgery, chemotherapy, concurrent chemo radiation and monoclonal antibodies.

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