Summary
Background
Data on the effects of coenzyme Q10 (CoQ10) supplementation on metabolic profiles among subjects with polycystic ovary syndrome (PCOS) are scarce.
Objective
This study was done to evaluate the effects of CoQ10 supplementation on glucose metabolism and lipid profiles in subjects with PCOS.
Design, Patients and Measurements
This randomized double-blind, placebo-controlled trial was conducted on 60 women diagnosed with PCOS. Subjects were randomly assigned into two groups to intake either 100 mg CoQ10 supplements (N=30) or placebo (N=30) per day for 12 weeks. Markers of insulin metabolism and lipid profiles were assessed at first and 12 weeks after the intervention.
Results
After 12 weeks of intervention, compared to the placebo, subjects who CoQ10 supplements had significantly decreased fasting plasma glucose (-0.24±0.51 vs. +0.01±0.44 mmol/L, P=0.04), serum insulin concentrations (-7.8±14.4 vs. +6.0±15.0 pmol/L, P<0.001), the homeostasis model of assessment-estimated insulin resistance (-0.3±0.6 vs. +0.2±0.6, P=0.001), the homeostasis model of assessment-estimated B cell function (-5.4±9.5 vs. +4.5±9.9, P<0.001) and increased the quantitative insulin sensitivity check index (+0.006±0.009 vs. -0.006±0.01, P<0.001). In addition, changes in serum total- (-0.10±0.48 vs. +0.19±0.50 mmol/L, P=0.02) and LDL-cholesterol concentrations (-0.15±0.40 vs. +0.14±0.49 mmol/L, P=0.01) in supplemented women were significantly different from those of women in the placebo group. When we adjusted the analysis for baseline values of biochemical parameters, age and baseline BMI, serum LDL-cholesterol (P=0.05) became non-significant, other findings did not alter.
Conclusions
Overall, CoQ10 supplementation for 12 weeks among subjects with PCOS had beneficial effects on glucose metabolism, serum total- and LDL-cholesterol levels.
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