Denosumab (Xgeva) [Internet].

Bone is a common site of metastasis for many cancers including breast, prostate, thyroid, lung, renal, and melanoma. Skeletal metastatic disease is the cause of considerable morbidity in patients with advanced cancer and has been associated with an increase in cancer-related pain, hypercalcemia, fractures, spinal instability, and compression of the spinal cord.

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