Thymoma-associated multi-organ autoimmunity: two cases and a review of the literature

Thymoma-associated multi-organ autoimmunity (TAMA) is defined as a disease of the liver, intestine, and skin, which histopathologically resembles graft-versus-host disease (GVHD).^1,2 Several sporadic cases imply that cutaneous manifestations of TAMA are associated with a poor prognosis.^2-5 However, it is difficult to examine the association because of the rarity of the disease. Herein we describe two cases of TAMA with cutaneous lesions and fatal courses, and review the literature with a focus on the prognosis.

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