Breaking Down Neighbors to Fuel Tumorigenesis

Publication date: 6 February 2017
Source:Developmental Cell, Volume 40, Issue 3
Author(s): John Vaughen, Tatsushi Igaki
Autophagy supports cell growth and survival autonomously by recycling intracellular proteins and/or organelles. Reporting in Nature, Katheder and colleagues (2017) find that tumors trigger non-autonomous autophagy in neighboring cells and distant organs, thus fueling tumor growth and metastasis. This opens new avenues for understanding and manipulating cancers through cell-cell communication.

Teaser

Autophagy supports cell growth and survival autonomously by recycling intracellular proteins/organelles. Reporting in Nature, Katheder and colleagues (2017) find that tumors trigger non-autonomous autophagy in neighboring cells and distant organs, thus fueling tumor growth and metastasis. This opens new avenues for understanding and manipulating cancers through cell-cell communication.


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