Cathepsin D as a promising target for the discovery of novel anticancer agents.

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Cathepsin D as a promising target for the discovery of novel anticancer agents.

Curr Cancer Drug Targets. 2016 Dec 29;:

Authors: Dubey V, Luqman S

Abstract
BACKGROUND: Cathepsin D (CATD), one of the aspartyl endoproteinase involved in different physiological processes and signaling pathways, is accountable for metabolic breakdown of intracellular proteins, activation of growth factors, hormones, and precursors of enzyme, processing of antigens, enzyme inhibitors and activators and regulation of apoptosis. Implication as a Target: Studies have confirmed the role and significance of CATD in an assortment of pathological conditions like Atherosclerosis, Alzheimer, Cancer, Cardiovascular, Huntington and Parkinson diseases. Amalgamated and veiled as inactive proCATD, it undergoes diverse cleavages to attain a desired conformation in an acidic milieu to act as a functionally active protein. In search of new candidate target (s) for cancer, CATD has attracted a wide group of investigators across the globe and is being recognized as a well defined marker in cancer especially for breast and hormone-dependent cancer.
METHODS: In this review, Pubmed, Sci-finder and other search engines were used to gather information on Catehpsin D. The necessary and relevant information was exploited to make the article an appropriate piece to highlight all the aspects related to Cathepsin D and its role in cancer. Findings & Conclusion: The present review illustrates structural, functional and regulatory aspects of CATD in cancer, its significant role in angiogenesis, metastasis, invasion, apoptosis, cell proliferation, and the therapeutic potential besides benefits of targeting CATD by natural products in cancer chemoprevention.

PMID: 28215160 [PubMed - as supplied by publisher]

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