Cortical Gray Matter MR Imaging in Multiple Sclerosis

Publication date: Available online 1 February 2017
Source:Neuroimaging Clinics of North America
Author(s): Massimiliano Calabrese, Marco Castellaro

Teaser

Several neuropathologic and imaging studies have consistently confirmed that multiple sclerosis affects both white (WM) and gray matter (GM) and that GM damage plays a key role in disability progression. However, differently from WM damage, the less inflammatory cell infiltration, the absence of significant blood-brain barrier damage, the low myelin density in upper cortical layers, as well as technical constraints, make the GM damage almost undetectable by means of conventional MR imaging.


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