Dose-time-response relationship in peanut allergy using a human model of passive cutaneous anaphylaxis

The extensive use of the double-blind, placebo-controlled oral food challenge in the diagnosis of food allergy and the growing uncertainties about the appropriate time interval between dose steps highlight the need to better understand which factors govern the reaction time in anaphylaxis, that is, the time it takes for an allergic reaction to develop after a patient has ingested the allergen.1 The purpose of this study was to determine whether the serum level of allergen specific IgE (sIgE) and/or the oral challenge dose affect the reaction time (Treact) and the size of the wheal (Swheal) in IgE-mediated, cutaneous reactions in vivo.

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