Excessive tau accumulation in the parieto-occipital cortex characterizes early-onset Alzheimer’s disease

Publication date: Available online 9 February 2017
Source:Neurobiology of Aging
Author(s): Hanna Cho, Jae Yong Choi, Seung Ha Lee, Jae Hoon Lee, Young Chul Choi, Young Hoon Ryu, Myoung Sik Lee, Chul Hyoung Lyoo
Early-onset Alzheimer's disease (EOAD) is characterized by greater non-memory dysfunctions, more rapid progression, and greater hypometabolism and atrophy than late-onset AD (LOAD). We sought to investigate the differences in tau accumulation patterns between early- and late-onset patients with AD and mild cognitive impairment (MCI). In 90 patients who completed ¹⁸F-AV-1451 and ¹⁸F-florbetaben positron emission tomography scans, only 59 amyloid-positive patients (11 EOAD, 10 EOMCI, 21 LOAD, and 17 LOMCI) were included in this study. We compared cortical ¹⁸F-AV-1451 binding between each patient group and corresponding amyloid-negative age-matched controls. In contrast to no difference in cortical binding between the EOMCI and LOMCI groups, EOAD showed greater binding in the parieto-occipital cortex than LOAD. The parieto-occipital binding correlated with visuospatial dysfunction in the EOAD spectrum, while binding in the temporal cortex correlated with verbal memory dysfunction in the LOAD spectrum. Our findings suggest that distinct topographic distribution of tau may influence the nature of cognitive impairment in EOAD patients.



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