Expression of cathepsin K in skull base chordoma.

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Expression of cathepsin K in skull base chordoma.

World Neurosurg. 2017 Feb 12;:

Authors: Tian K, Ma J, Wang L, Wang K, Li D, Hao S, Yang Y, Du J, Jia G, Zhang L, Wu Z, Zhang J

Abstract
OBJECTIVE: The objective of this study is to explore the association between cathepsin K and the clinical characteristics of skull base chordoma (SBC).
METHODS: In this study, 58 paraffin-embedded samples and 85 frozen samples of 94 patients were included. All clinical data corresponding to these patients were available. Immunohistochemical staining and Quantitative Real-time polymerase chain reaction were performed. Positive rate of Immunohistochemical staining slices and delta CT value of Quantitative Real-time polymerase chain reaction represent the cathepsin K expression level in protein and gene level separately.
RESULTS: In protein level, the expression level (EL) of invasive tumors was increased compared to non-invasive tumors (p=0.006), EL of tumors with dura erosion was increased compared to tumors without dura erosion (p=0.001). Tumors with septa exhibited increased EL compared to tumors without septa (p=0.001). Tumors with lobulation exhibited increased EL compared to tumors without lobulation (p=0.000). And higher EL of cathepsin K was associated with reduced PFS (p=0.015). In gene level, tumors with septa showed higher EL than tumors without septa (p=0.015), and tumors with lobulation showed higher EL than tumors without lobulation (p=0.049). And cathepsin K EL was an independent risk factors for reduced PFS, an increased level of cathepsin K in SBC was associated with reduced PFS (p=0.042).
CONCLUSIONS: Increased cathepsin K expression in SBC was associated with tumor invasion and reduced PFS. Our results also indicated that the cathepsin K level in SBC was associated with tumor stage, tumor lobulation condition and septa condition.

PMID: 28216213 [PubMed - as supplied by publisher]

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