Group 2 innate lymphoid cell activation in the neonatal lung drives type 2 immunity and allergen sensitization

Publication date: Available online 17 February 2017
Source:Journal of Allergy and Clinical Immunology
Author(s): Catherine A. Steer, Itziar Martinez-Gonzalez, Maryam Ghaedi, Patricia Allinger, Laura Mathä, Fumio Takei

Teaser

Neonatal lung immunity is unique due to allergen-independent endogenous IL-33 mediated activation of group 2 innate lymphoid cells (ILC2s) that promote Th2 cell responses, making neonates prone to allergen sensitization and allergic lung diseases.


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