Lipidomic Adaptations in White and Brown Adipose Tissue in Response to Exercise Demonstrate Molecular Species-Specific Remodeling

Publication date: 7 February 2017
Source:Cell Reports, Volume 18, Issue 6
Author(s): Francis J. May, Lisa A. Baer, Adam C. Lehnig, Kawai So, Emily Y. Chen, Fei Gao, Niven R. Narain, Liubov Gushchina, Aubrey Rose, Andrea I. Doseff, Michael A. Kiebish, Laurie J. Goodyear, Kristin I. Stanford
Exercise improves whole-body metabolic health through adaptations to various tissues, including adipose tissue, but the effects of exercise training on the lipidome of white adipose tissue (WAT) and brown adipose tissue (BAT) are unknown. Here, we utilize MS/MS^ALL shotgun lipidomics to determine the molecular signatures of exercise-induced adaptations to subcutaneous WAT (scWAT) and BAT. Three weeks of exercise training decrease specific molecular species of phosphatidic acid (PA), phosphatidylcholines (PC), phosphatidylethanolamines (PE), and phosphatidylserines (PS) in scWAT and increase specific molecular species of PC and PE in BAT. Exercise also decreases most triacylglycerols (TAGs) in scWAT and BAT. In summary, exercise-induced changes to the scWAT and BAT lipidome are highly specific to certain molecular lipid species, indicating that changes in tissue lipid content reflect selective remodeling in scWAT and BAT of both phospholipids and glycerol lipids in response to exercise training, thus providing a comprehensive resource for future studies of lipid metabolism pathways.

Graphical abstract

Teaser

Using an MS/MS^ALL shotgun lipidomics approach, May et al. demonstrate that exercise causes a molecular species-specific remodeling of subcutaneous white adipose tissue (scWAT) and brown adipose tissue (BAT). These species-specific changes are depot dependent (divergent changes in scWAT versus BAT) and specific to the stimulus (exercise-induced adaptations to the BAT lipidome are distinct from cold-induced changes to the BAT lipidome).


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