Blood eosinophils predict therapeutic effects of a GATA3-specific DNAzyme in asthma patients

Publication date: Available online 22 March 2017
Source:Journal of Allergy and Clinical Immunology
Author(s): Norbert Krug, Jens M. Hohlfeld, Roland Buhl, Jonas Renz, Holger Garn, Harald Renz

Teaser

The effect of the GATA3-mRNA-specific DNAzyme SB010 treatment on EAR and LAR responses continuously increased with higher relative levels of blood eosinophils making them a suitable biomarker to stratify asthma patients for inhaled SB010 treatment.


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