Choosing wisely - Preclinical test models in the era of precision medicine.

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Choosing wisely - Preclinical test models in the era of precision medicine.

Cancer Treat Rev. 2017 Mar 06;55:36-45

Authors: Klinghammer K, Walther W, Hoffmann J

Abstract
Through the introduction of a steadily growing variety of preclinical test models drug development and biomarker research has advanced. Next to classical used 2D cell line cultures, tissue-slice cultures, 3D organoid cell cultures, genetically engineered mouse models, cell line derived mouse models and patient derived xenografts may be selected for a specific question. All models harbor advantages and disadvantages. This review focuses on the available preclinical test models, novel developments such as humanized mice and discusses for which question a particular model should be employed.

PMID: 28314175 [PubMed - as supplied by publisher]

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