Increase in sensory sensitivity around, but not in the central part of, the hyperkeratotic papule in lichen amyloidosis

Abstract

Lichen amyloidosis (LA) is an itchy skin disorder characterized by amyloid deposits in the superficial dermis. Pruritus is the presenting symptom in 90% of LA patients.¹ However, the underlying mechanisms and mediators of pruritus in LA remain unclear.

One LA patient complained of severe pruritus in the hyperkeratotic papules, especially around the papule.

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