Small lymphocytic lymphoma with Reed Sternberg cells: a diagnostic dilemma.

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Small lymphocytic lymphoma with Reed Sternberg cells: a diagnostic dilemma.

BMJ Case Rep. 2017 Feb 14;2017:

Authors: Pervez S, Abro B, Shahbaz H

Abstract
Reed Sternberg (RS) cells in the setting of small lymphocytic lymphoma (SLL) can complicate the histopathological diagnosis. We report a case of a man aged 54 years who presented with cervical lymphadenopathy. Resection of the lymph node was performed and sent for histopathological evaluation to a local laboratory. A diagnosis of SLL with Classic Hodgkin's lymphoma (CHL) was made. The medical oncologist who encountered this diagnosis for the first time sent the biopsy blocks to our laboratory for a second opinion. On review of the biopsy and immunohistochemical stains, it showed typical SLL morphology and immunophenotype. Focally, it showed large mononuclear RS type cells; however, no typical background of CHL was seen. The diagnosis was revised to 'SLL with RS like cells with no convincing evidence of CHL'. The patient was subsequently treated as a case of SLL and no progression was observed on a follow-up of 5 years.

PMID: 28196821 [PubMed - indexed for MEDLINE]

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