Synthesis of novel C-9 carbon substituted derivatives of Artemisinin

Publication date: Available online 14 March 2017
Source:Bioorganic & Medicinal Chemistry
Author(s): Daniel Meyer, Toni Smeilus, Dimanthi Pliatsika, Farnoush Mousavizadeh, Athanassios Giannis
Several artemisinin derivatives carrying several groups (alkyl, hydroxyalkyl, allyl or azide) at position 9 have been synthesized starting from artemisinin via enolate formation and subsequent reaction with appropiate electrophiles.

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