Cavernoma: New insights from an unusual case.

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Cavernoma: New insights from an unusual case.

World Neurosurg. 2017 Apr 01;:

Authors: Sokratous G, Ughratdar I, Selway R, Al-Sarraj S, Ashkan K

Abstract
Rapid growth in cerebral cavernous malformation is rare. We present the case of a 71 year old patient with known multiple cavernomas over many years in whom one lesion showed rapid expansion in size. Histological examination revealed co-existence of glioblastoma within the cavernoma. We review the literature for similar cases and discuss the potential mechanisms underlying this phenomenon. Review of the literature revealed four cases with known cerebral cavernous malformations that have later developed, at the same site, a high grade glioma. All reported cases involve female patients with age ranging from 25 to 71, with imaging confirming rapid growth in the lesion. We conclude that although rare, rapid expansion of existing cavernoma should be treated as suspicious for development of other malignant tumors, and propose adding the possibility of chronic inflammation in the surrounding brain caused by micro-bleeds and hemosiderin deposition from the cavernoma to the list of possible causes.

PMID: 28377258 [PubMed - as supplied by publisher]

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