[Clinical and neuropathological characteristics of dementia with Lewy bodies].

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[Clinical and neuropathological characteristics of dementia with Lewy bodies].

Orv Hetil. 2017 Apr;158(17):643-652

Authors: Bencze J, Simon V, Bereczki E, Majer R, Varkoly G, Murnyák B, Kálmán J, Hortobágyi T

Abstract
Dementia with Lewy bodies (DLB) is the second most common neurodegenerative dementia. The accurate diagnosis is often possible only by neuropathological examination. The morphologic hallmarks are the presence of α-synuclein-rich Lewy bodies and Lewy neurites, identical to those seen in Parkinson's disease (PD) and Parkinson's disease dementia (PDD). Neurotransmitter deficits, synaptic and ubiquitin-proteasome system (UPS) dysfunction play major role in the pathomechanism. Characteristic symptoms are cognitive fluctuation, parkinsonism and visual hallucinations. Due to the often atypical clinical presentation novel imaging techniques and biomarkers could help the early diagnosis. Although curative treatment is not available, therapies can improve quality of life. Clinicopathological studies are important in exploring pathomechanisms, ensuring accurate diagnosis and identifying therapeutic targets. Orv Hetil. 2017; 158(17): 643-652.

PMID: 28434243 [PubMed - in process]

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