DEAD-Box RNA Binding Protein DDX5: Not a Black-Box during Reprogramming

Publication date: 6 April 2017
Source:Cell Stem Cell, Volume 20, Issue 4
Author(s): Christian M. Nefzger, Jose M. Polo
The role of RNA binding proteins (RBPs) during nuclear reprogramming is poorly characterized. In this issue of Cell Stem Cell,Li et al. (2017) show that DEAD-box RBP DDX5 acts as a reprogramming roadblock and give important mechanistic insights into the establishment of pluripotency by characterizing the intricate downstream events.

Teaser

The role of RNA binding proteins (RBPs) during nuclear reprogramming is poorly characterized. In this issue of Cell Stem Cell, Li et al. (2017) show that DEAD-box RBP DDX5 acts as a reprogramming roadblock and give important mechanistic insights into the establishment of pluripotency by characterizing the intricate downstream events.


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