Novel GOPC(FIG)-ROS1 fusion in a pediatric high-grade glioma survivor.

Novel GOPC(FIG)-ROS1 fusion in a pediatric high-grade glioma survivor.

J Neurosurg Pediatr. 2017 Apr 07;:1-5

Authors: Kiehna EN, Arnush MR, Tamrazi B, Cotter JA, Hawes D, Robison NJ, Fong CY, Estrine DB, Han JH, Biegel JA

Abstract
Pediatric high-grade glioma is a rare tumor characterized by high mortality. The authors report the first case of a high-grade glioma associated with a GOPC(FIG)-ROS1 fusion in a pediatric patient. The patient underwent gross-total resection at the age of 4 years, followed by adjuvant high-dose chemotherapy and autologous hematopoietic stem cell rescue. At 30 months after transplantation, she remains disease free.

PMID: 28387643 [PubMed - as supplied by publisher]

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