Preclinical to Phase II Amyloid beta (Aβ) peptide modulators under investigation for Alzheimer's disease.

Preclinical to Phase II Amyloid beta (Aβ) peptide modulators under investigation for Alzheimer's disease.

Expert Opin Investig Drugs. 2017 Mar 31;:

Authors: Parsons CG, Rammes G

Abstract
INTRODUCTION: Alzheimer disease (AD) is the most common form of dementia and its incidence is increasing at an alarming rate all over the world. The pathophysiology of AD is characterized by chronic, progressive neurodegeneration which involves early synaptotoxicity. One of the most obvious pathological feature of AD is the accumulation of amyloid-β (Aβ) in the brain. Since current treatment options only provide symptomatic help and Aβ is thought to underlie early synaptic pathology, Aβ reduction in the brain may be a promising therapeutic strategy in preventing and /or reversing AD-related dysfunction Areas covered: This paper outlines and evaluates the current landscape of preclinical and clinical studies focusing on modulating Aβ pathophysiology. Data and analysis for this review were procured from PubMed, clinicaltrials.gov, Alzforum. Expert opinion: According to current knowledge, reducing Aβ production offers numerous treatment options. However, targeting the initial steps by pharmacological interference with secretases is challenging due to the emergence of various side effects. The most promising approach seems to be the prevention of early Aβ oligomerization. Combination approaches targeting both Aβ and tau would seem to be another promising approach that could have beneficial effects through the course of the disease.

PMID: 28362514 [PubMed - as supplied by publisher]

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