Chemotherapy With Si-Rna And Anti-Cancer Drugs.

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Chemotherapy With Si-Rna And Anti-Cancer Drugs.

Curr Drug Deliv. 2017 May 18;:

Authors: Kaur K, Rath G, Chandra S, Singh R, Goyal AK

Abstract
To treat cancer, chemotherapy is a key therapeutic approach which is associated with several limitations. This chemotherapeutical agents exhibit multi drug resistance coupled with undesirable side effects. This multidrug resistance is exhibited by tumor cell due to actuation of drug out flow mechanism, programmed cell death and protection mechanisms etc. One of the therapeutic approaches to cure cancer is RNA interference (RNAi). Small interfering RNA (si-RNA) is considered as a major therapeutic tool used to control expression of a particular gene. It is a well known fact that intake of more drugs can lead to cancer chemo resistance, thus siRNA based therapeutic approach is under scrutiny to cure cancer. Mostly cancer cells in patients who are on chemotherapy show withdrawal effects over the course of treatment. These symptoms usually observed in cancer cells patients acquire defense mechanism by over expression of drug efflux pumps, increased metabolism of drug, self repairing capability enhancement and expressing the altered drug targets. Thus combination chemotherapy is employed in clinics as a main cancer treatment tool to suppress multidrug resistance in cancer. On the other hand, suitable protective carrier is needed due to stability issues and small size of si-RNA. To overcome these drawbacks associated with siRNA currently, nanotechnology based approaches have been widely used. This review study explores the delivery of si-RNA in combination with other anticancer agents for cancer treatment.

PMID: 28521675 [PubMed - as supplied by publisher]

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