Hailey–Hailey disease successfully controlled with low-dose naltrexone

Hailey–Hailey disease, or familial benign pemphigus, is a chronic, autosomal dominant or rarely sporadic condition characterized by painful erosions and macerations in the skin folds. Classically, treatment options for this condition include topical steroids, topical and systemic retinoids, and immunomodulators such as methotrexate. Although low-dose naltrexone (LDN) has never been reported in the literature as a treatment for Hailey–Hailey, patients on online blogs, websites, and Facebook support groups have attested to the success of this relatively benign medication in the treatment of their disease.

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