Mature aggressive B-cell lymphoma across age groups - molecular advances and therapeutic implications.

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Mature aggressive B-cell lymphoma across age groups - molecular advances and therapeutic implications.

Expert Rev Hematol. 2017 Feb;10(2):123-135

Authors: Lange J, Lenz G, Burkhardt B

Abstract
INTRODUCTION: Mature B-cell lymphoma represents the most common type of Non-Hodgkin lymphoma, and different subtypes prevail at different patient ages. Areas covered: We review recent data on differences and commonalities in mature B-cell lymphoma occurring in adult and pediatric patients, with a special emphasis on molecular advances and therapeutic implications. To this end, we will discuss knowledge on diffuse large B-cell lymphoma and Burkitt lymphoma/leukemia, which are the most frequent subtypes in adult and pediatric patients, respectively, and on primary mediastinal B-cell lymphoma, which is a subtype of mature B-cell lymphoma occurring mainly in adolescents and young adults with a female predominance. Expert commentary: Molecular profiling has revealed molecular alterations that can be used to further classify the subtypes of mature B-cell lymphoma. These new subgroups frequently respond differentially to targeted therapeutic strategies. Future clinical trials utilizing new drugs will address this issue by combining clinical data and response assessment with a molecular workup of the corresponding lymphomas.

PMID: 27936978 [PubMed - indexed for MEDLINE]

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