Targeting Histamine Receptors in Irritable Bowel Syndrome: A Critical Appraisal.

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Targeting Histamine Receptors in Irritable Bowel Syndrome: A Critical Appraisal.

J Neurogastroenterol Motil. 2017 May 27;:

Authors: Fabisiak A, Włodarczyk J, Fabisiak N, Storr M, Fichna J

Abstract
Irritable bowel syndrome is a group of functional gastrointestinal disorders with not yet fully clarified etiology. Recent evidence suggesting that mast cells may play a central role in the pathogenesis of irritable bowel syndrome paves the way for agents targeting histamine receptors as a potential therapeutic option in clinical treatment. In this review, the role of histamine and histamine receptors is debated. Moreover, the clinical evidence of anti-histamine therapeutics in irritable bowel syndrome is discussed.

PMID: 28551943 [PubMed - as supplied by publisher]

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