The AGES-Reykjavik study atlases: Non-Linear multi-Spectral template and atlases for studies of the ageing brain

Publication date: Available online 6 May 2017
Source:Medical Image Analysis
Author(s): Lars Forsberg, Sigurdur Sigurdsson, Jesper Fredriksson, Asdis Egilsdottir, Bryndis Oskarsdottir, Olafur Kjartansson, Mark A. van Buchem, Lenore J. Launer, Vilmundur Gudnason, Alex Zijdenbos
Quantitative analyses of brain structures from Magnetic Resonance (MR) image data are often performed using automatic segmentation algorithms. Many of these algorithms rely on templates and atlases in a common coordinate space. Most freely available brain atlases are generated from relatively young individuals and not always derived from well-defined cohort studies. In this paper, we introduce a publicly available multi-spectral template with corresponding tissue probability atlases and regional atlases, optimised to use in studies of ageing cohorts (mean age 75± 5 years). Furthermore, we provide validation data from a regional segmentation pipeline to assure the integrity of the dataset.

Graphical abstract

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