Publication date: Available online 28 June 2017
Source:Vaccine
Author(s): Un-In Wu, Szu-Min Hsieh, Wen-Sen Lee, Ning-Chi Wang, Hsiang-Chi Kung, Tsong-Yih Ou, Fu-Lun Chen, Te-Yu Lin, Yee-Chun Chen, Shan-Chwen Chang
BackgroundWe conducted a phase I/II clinical trial to evaluate the safety and immunogenicity of a Madin-Darby canine kidney (MDCK) cell-grown inactivated H7N9 influenza vaccine for pandemic preparedness purposes.MethodsBetween April 7, 2015 and May 27, 2016, healthy adults aged 20–60years were enrolled sequentially in phase I (n=40) and phase II (n=160) from three hospitals in Taiwan and randomized to receive 2 doses of whole-virus H7N9 vaccine (15 or 30μg hemagglutinin antigen (HA) with or without an aluminum hydroxide adjuvant) at 21-day intervals. Safety up to 180days and changes in hemagglutinin inhibition (HI) titers at 21days after each vaccination were determined.ResultsOf the 200 randomized subjects, 193 (96.5%) received 2 doses of the study vaccine and were included in the intention-to-treat analysis for safety, and 190 (95%) were included in the per-protocol analysis for immunogenicity. Most adverse events were mild and transient; no death or vaccine-related serious adverse events were reported. Overall, higher immune responses were observed in the groups administered with 30μgHA formulation than in the other two groups administered with 15μgHA formulation. The highest immune response was observed in subjects who received 2 doses of the adjuvanted vaccine containing 30μgHA with HI titer, seroprotection rate, seroconversion rate, and seroconversion factor of 36.2, 64.6%, 64.6% and 5.7, respectively.ConclusionsOur study demonstrated that the H7N9 influenza vaccine containing 30µgHA with aluminum hydroxide adjuvant was immunogenic and safe in adults aged 20–60years.CLINICALTRIALS.GOV identifier: NCT02436928.
http://ift.tt/2tqIMlN
Σφακιανάκης Αλέξανδρος
ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5 Άγιος Νικόλαος
Κρήτη 72100
00302841026182
00306932607174
alsfakia@gmail.com
Αρχειοθήκη ιστολογίου
-
►
2023
(391)
- ► Φεβρουαρίου (200)
- ► Ιανουαρίου (191)
-
►
2022
(2843)
- ► Δεκεμβρίου (161)
- ► Σεπτεμβρίου (219)
- ► Φεβρουαρίου (264)
- ► Ιανουαρίου (280)
-
►
2021
(5625)
- ► Δεκεμβρίου (231)
- ► Σεπτεμβρίου (345)
- ► Φεβρουαρίου (620)
-
►
2020
(2065)
- ► Δεκεμβρίου (535)
- ► Σεπτεμβρίου (222)
- ► Φεβρουαρίου (28)
-
►
2019
(9608)
- ► Δεκεμβρίου (19)
- ► Σεπτεμβρίου (54)
- ► Φεβρουαρίου (3791)
- ► Ιανουαρίου (3737)
-
►
2018
(69720)
- ► Δεκεμβρίου (3507)
- ► Σεπτεμβρίου (3851)
- ► Φεβρουαρίου (8116)
- ► Ιανουαρίου (7758)
-
▼
2017
(111579)
- ► Δεκεμβρίου (7718)
- ► Σεπτεμβρίου (7549)
-
▼
Ιουνίου
(10489)
-
▼
Ιουν 29
(349)
- A Quadrangular Flap Technique for Vermilion Repair...
- Incarcerated congenital transmesenteric hernia in ...
- Traumatic diaphragmatic rupture with underlying lu...
- Hybrid approach to the management of infective end...
- Acne keloidalis nuchae: risk factors and associate...
- Severe colloid milium presenting as papillomatosis...
- Intrinsic and Extrinsic Causes of Malignancies in ...
- An elusive ciliopathy: Joubert syndrome
- Endogenous endophthalmitis and osteomyelitis assoc...
- ILF2 Is a Regulator of RNA Splicing and DNA Damage...
- Association between severity of untreated Sleep Ap...
- Actigraphy scoring for sleep outcome measures in c...
- Reviewing the impact of lipid synthetic flux on Th...
- Successful management of primary atrophic rhinitis...
- Successful management of primary atrophic rhinitis...
- A prospective randomized cost billing comparison o...
- Response to comments on: A prospective randomized ...
- Commentary on The New Opt-Out Dutch National Breas...
- Recent trends for the removal of colored particles...
- Letter to the editor
- Letter to the editor
- Would brief alcohol intervention be helpful in fac...
- I125 brachytherapy guided by individual three-dime...
- Long-term influence of mandibular advancement on t...
- Body talk, weight status, and pathological eating ...
- ‘My lips are sealed’ - The impact of package resea...
- Randomised controlled trial of a text messaging in...
- Consumption of key food groups during the postpart...
- Modelling and Extraction of Pulsatile Radial Diste...
- Estimation of individual axon bundle properties by...
- Guest editors of MICCAI 2016 Special Issues of Med...
- Cross-sectional association of coffee and caffeine...
- The medial pterygoid muscle: a stabilizer of horiz...
- Long-term stability of limiting nasal alar base wi...
- Method of osteotomy fixation and need for removal ...
- Vertebral anomalies in craniofacial microsomia: a ...
- Relaxation induced by the nitric oxide donor and c...
- Freeze dried solid dispersion of exemestane: A way...
- Investigating therapeutic usage of combined Ticagr...
- Transcriptional Consequences of XPA Disruption in ...
- Pressure and Flow Comparisons Across Vocal Patholo...
- Appendiceal Mucinous Neoplasms: Diagnosis and Mana...
- Reduction of severe oropharyngeal hemorrhage follo...
- Label-free electrochemiluminescence assay for aque...
- Field-effect transition sensor for KI detection ba...
- Fluorescent carbon nanoparticle-based lateral flow...
- Mice exposure to tannery effluents changes their o...
- Bacterial periphytic communities related to mercur...
- Successful management of primary atrophic rhinitis...
- Cáncer de Tiroides: Síntomas de la enfermedad en H...
- ¿En qué casos se realiza la prueba de la hormona e...
- Hipertiroidismo y aumento de peso: ¿cómo podemos c...
- Conoce los diferentes tipos de operación de tiroid...
- Enfermedad de Graves: Síntomas e información de in...
- Conoce los síntomas del Nódulo Tiroideo
- ¿Cuándo es recomendable una dieta baja en yodo?
- ¿Cuáles son los valores normales de TSH (Análisis ...
- Otoplasty for prominent ears – demographics and su...
- Sleep quality and communication aspects in children
- Adenotonsillectomy outcomes in children with sleep...
- Efficient model calibration method based on phase ...
- Biogeochemical and engineered barriers for prevent...
- Overview of Cancer Stem Cells and Stemness for Com...
- Medical Examiners Say Sleep Apnea Contributed to C...
- Viral Replication Complexes Are Targeted by LC3-Gu...
- Cutaneous Leishmaniasis Induces a Transmissible Dy...
- Heart Failure in Epidermolysis Bullosa
- Mycosis Fungoides in Pediatric Patients: A Diagnos...
- Eosinophils as a Warning Sign
- Antimicrobial Photodynamic Therapy: An Unexplored ...
- Eosinophilic Dermatosis of Hematologic Malignancy
- Considerations on Subgroup Analyses in Clinical Tr...
- Psoriasis and Psychiatric Disorders: The Next Fron...
- Psoriasis and Nonalcoholic Fatty Liver Disease
- Angiogenesis in Dermatology – Insights of Molecula...
- Hair-follicle Transplant Into Chronic Ulcers: A Ne...
- Follicular Unit Extraction for Hair Transplantatio...
- Causes and Cures of Skin Diseases in the Work of H...
- Cardiomyopathy in Patients With Hereditary Bullous...
- Comparison of ixekizumab with etanercept or placeb...
- Mycosis Fungoides: Experience in a Pediatric Hospital
- Pediatric Allergic Contact Dermatitis: Clinical an...
- Photodynamic Therapy With Methylene Blue for Skin ...
- Multiple Papules on Both Hands
- Nodule on the External Ear
- RF-Itraconazole Pulse Therapy for Seborrheic Derma...
- Ludwigia octovalvis extract improves glycemic cont...
- IFC (Journal of Ethnopharmacology)
- Rheopheresis in treatment of idiopathic sensorineu...
- Rheopheresis in treatment of idiopathic sensorineu...
- Simultaneous Versus Sequential Ptosis and Strabism...
- Intrinsic and Extrinsic Causes of Malignancies in ...
- Antibiotics Improve Short-Term Outcomes for Simple...
- Reconstructive endovascular treatment of vertebral...
- A Multicenter Pivotal Study to Evaluate Tissue Sta...
- Commentary on The Clinical and Histological Effect...
- Commentary on The Facial Platysma and Its Underapp...
- Pulsed Dye Laser Treatment of a Nonhealing Chronic...
- Treatment Patterns, Outcomes, and Patient Satisfac...
- In a Pinch? Rocker-Slide Punch Biopsy Technique.
-
▼
Ιουν 29
(349)
- ► Φεβρουαρίου (10753)
- ► Ιανουαρίου (10529)
-
►
2016
(16402)
- ► Δεκεμβρίου (7478)
- ► Φεβρουαρίου (900)
- ► Ιανουαρίου (1250)
! # Ola via Alexandros G.Sfakianakis on Inoreader
Η λίστα ιστολογίων μου
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
Αρχειοθήκη ιστολογίου
-
►
2023
(391)
- ► Φεβρουαρίου (200)
- ► Ιανουαρίου (191)
-
►
2022
(2843)
- ► Δεκεμβρίου (161)
- ► Σεπτεμβρίου (219)
- ► Φεβρουαρίου (264)
- ► Ιανουαρίου (280)
-
►
2021
(5625)
- ► Δεκεμβρίου (231)
- ► Σεπτεμβρίου (345)
- ► Φεβρουαρίου (620)
-
►
2020
(2065)
- ► Δεκεμβρίου (535)
- ► Σεπτεμβρίου (222)
- ► Φεβρουαρίου (28)
-
►
2019
(9608)
- ► Δεκεμβρίου (19)
- ► Σεπτεμβρίου (54)
- ► Φεβρουαρίου (3791)
- ► Ιανουαρίου (3737)
-
►
2018
(69720)
- ► Δεκεμβρίου (3507)
- ► Σεπτεμβρίου (3851)
- ► Φεβρουαρίου (8116)
- ► Ιανουαρίου (7758)
-
▼
2017
(111579)
- ► Δεκεμβρίου (7718)
- ► Σεπτεμβρίου (7549)
-
▼
Ιουνίου
(10489)
-
▼
Ιουν 29
(349)
- A Quadrangular Flap Technique for Vermilion Repair...
- Incarcerated congenital transmesenteric hernia in ...
- Traumatic diaphragmatic rupture with underlying lu...
- Hybrid approach to the management of infective end...
- Acne keloidalis nuchae: risk factors and associate...
- Severe colloid milium presenting as papillomatosis...
- Intrinsic and Extrinsic Causes of Malignancies in ...
- An elusive ciliopathy: Joubert syndrome
- Endogenous endophthalmitis and osteomyelitis assoc...
- ILF2 Is a Regulator of RNA Splicing and DNA Damage...
- Association between severity of untreated Sleep Ap...
- Actigraphy scoring for sleep outcome measures in c...
- Reviewing the impact of lipid synthetic flux on Th...
- Successful management of primary atrophic rhinitis...
- Successful management of primary atrophic rhinitis...
- A prospective randomized cost billing comparison o...
- Response to comments on: A prospective randomized ...
- Commentary on The New Opt-Out Dutch National Breas...
- Recent trends for the removal of colored particles...
- Letter to the editor
- Letter to the editor
- Would brief alcohol intervention be helpful in fac...
- I125 brachytherapy guided by individual three-dime...
- Long-term influence of mandibular advancement on t...
- Body talk, weight status, and pathological eating ...
- ‘My lips are sealed’ - The impact of package resea...
- Randomised controlled trial of a text messaging in...
- Consumption of key food groups during the postpart...
- Modelling and Extraction of Pulsatile Radial Diste...
- Estimation of individual axon bundle properties by...
- Guest editors of MICCAI 2016 Special Issues of Med...
- Cross-sectional association of coffee and caffeine...
- The medial pterygoid muscle: a stabilizer of horiz...
- Long-term stability of limiting nasal alar base wi...
- Method of osteotomy fixation and need for removal ...
- Vertebral anomalies in craniofacial microsomia: a ...
- Relaxation induced by the nitric oxide donor and c...
- Freeze dried solid dispersion of exemestane: A way...
- Investigating therapeutic usage of combined Ticagr...
- Transcriptional Consequences of XPA Disruption in ...
- Pressure and Flow Comparisons Across Vocal Patholo...
- Appendiceal Mucinous Neoplasms: Diagnosis and Mana...
- Reduction of severe oropharyngeal hemorrhage follo...
- Label-free electrochemiluminescence assay for aque...
- Field-effect transition sensor for KI detection ba...
- Fluorescent carbon nanoparticle-based lateral flow...
- Mice exposure to tannery effluents changes their o...
- Bacterial periphytic communities related to mercur...
- Successful management of primary atrophic rhinitis...
- Cáncer de Tiroides: Síntomas de la enfermedad en H...
- ¿En qué casos se realiza la prueba de la hormona e...
- Hipertiroidismo y aumento de peso: ¿cómo podemos c...
- Conoce los diferentes tipos de operación de tiroid...
- Enfermedad de Graves: Síntomas e información de in...
- Conoce los síntomas del Nódulo Tiroideo
- ¿Cuándo es recomendable una dieta baja en yodo?
- ¿Cuáles son los valores normales de TSH (Análisis ...
- Otoplasty for prominent ears – demographics and su...
- Sleep quality and communication aspects in children
- Adenotonsillectomy outcomes in children with sleep...
- Efficient model calibration method based on phase ...
- Biogeochemical and engineered barriers for prevent...
- Overview of Cancer Stem Cells and Stemness for Com...
- Medical Examiners Say Sleep Apnea Contributed to C...
- Viral Replication Complexes Are Targeted by LC3-Gu...
- Cutaneous Leishmaniasis Induces a Transmissible Dy...
- Heart Failure in Epidermolysis Bullosa
- Mycosis Fungoides in Pediatric Patients: A Diagnos...
- Eosinophils as a Warning Sign
- Antimicrobial Photodynamic Therapy: An Unexplored ...
- Eosinophilic Dermatosis of Hematologic Malignancy
- Considerations on Subgroup Analyses in Clinical Tr...
- Psoriasis and Psychiatric Disorders: The Next Fron...
- Psoriasis and Nonalcoholic Fatty Liver Disease
- Angiogenesis in Dermatology – Insights of Molecula...
- Hair-follicle Transplant Into Chronic Ulcers: A Ne...
- Follicular Unit Extraction for Hair Transplantatio...
- Causes and Cures of Skin Diseases in the Work of H...
- Cardiomyopathy in Patients With Hereditary Bullous...
- Comparison of ixekizumab with etanercept or placeb...
- Mycosis Fungoides: Experience in a Pediatric Hospital
- Pediatric Allergic Contact Dermatitis: Clinical an...
- Photodynamic Therapy With Methylene Blue for Skin ...
- Multiple Papules on Both Hands
- Nodule on the External Ear
- RF-Itraconazole Pulse Therapy for Seborrheic Derma...
- Ludwigia octovalvis extract improves glycemic cont...
- IFC (Journal of Ethnopharmacology)
- Rheopheresis in treatment of idiopathic sensorineu...
- Rheopheresis in treatment of idiopathic sensorineu...
- Simultaneous Versus Sequential Ptosis and Strabism...
- Intrinsic and Extrinsic Causes of Malignancies in ...
- Antibiotics Improve Short-Term Outcomes for Simple...
- Reconstructive endovascular treatment of vertebral...
- A Multicenter Pivotal Study to Evaluate Tissue Sta...
- Commentary on The Clinical and Histological Effect...
- Commentary on The Facial Platysma and Its Underapp...
- Pulsed Dye Laser Treatment of a Nonhealing Chronic...
- Treatment Patterns, Outcomes, and Patient Satisfac...
- In a Pinch? Rocker-Slide Punch Biopsy Technique.
-
▼
Ιουν 29
(349)
- ► Φεβρουαρίου (10753)
- ► Ιανουαρίου (10529)
-
►
2016
(16402)
- ► Δεκεμβρίου (7478)
- ► Φεβρουαρίου (900)
- ► Ιανουαρίου (1250)
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου