Ultrastructural alterations of renal tissue in a male patient with Fabry’s disease

Publication date: Available online 23 June 2017
Source:Alexandria Journal of Medicine
Author(s): Farahnaz Noroozinia, Khadijah Makhdoomi, Amir Abbas Farshid
BackgroundFabry's disease is an X-linked lipid storage disorder due to deficient lysosomal alpha galactosidase A.Case PresentationKidney biopsy was done on a 19year old male patient with complaint of acroparesthesia, maculopapular skin lesions and cornea verticillata. Kidney biopsy tissue was processed and examined by electron microscopy. Changes were inclusion bodies in the cytoplasm of the renal cells. These inclusions were osmophilic with concentric lamellation of clear and dark layers, showing onion skin appearance. The podocytes were mostly affected and some of the foot processes were fused. Cross-sections of collagen fibers were also evident, indicating fibrosis.ConclusionThe ultra-structure of the kidney clearly showed the intra-cytoplasmic glycosphingolipid accumulation in renal cells, responsible for progressive decline in renal function which could lead to kidney failure. The final diagnosis of Fabry's disease was confirmed. In the present case-study, electron microscopy proved to be a valuable diagnostic aid.



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