d-Tyrosyl-tRNA Deacylase: A New Function

Publication date: Available online 29 July 2017
Source:Trends in Biochemical Sciences
Author(s): Richard Calendar
d-Aminoacyl-tRNA deacylase (DTD) hydrolyzes d-amino acids mistakenly attached to tRNAs and, thus, has been implicated in perpetuating protein homochirality. Fifty years after the discovery of DTD, it has now been shown that its function extends beyond 'chiral proofreading' because it also eliminates glycine that has been erroneously coupled to tRNA^Ala.



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