Inhibition of P-glycoprotein stimulates cell death under Hypoxia-mimicking conditions.

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Inhibition of P-glycoprotein stimulates cell death under Hypoxia-mimicking conditions.

Dokl Biochem Biophys. 2017 Jan;472(1):27-30

Authors: Vdovin AS, Maximchik PV, Kulikov AV, Zhivotovsky BD, Gogvadze VG

Abstract
The most common drug resistance mechanism in tumor cells is expression on their surface of the energy-dependent pump like P-glycoprotein (P-gp) that expels chemotherapeutic agents from the interior. An imitation of the hypoxic condition by the iron chelator deferoxamine caused Hypoxia-inducible factor 1-alpha (HIF-1α) stabilization and inhibition of doxorubicin-induced apoptosis in colon cancer НСТ116 cells. P-gp blocker verapamil suppressed doxorubicin accumulation leading to cell death induction. Considering these results, P-gp may be used as a potential target to stimulate chemotherapeutic drugs activity that will contribute to more efficient tumor cells elimination.

PMID: 28421447 [PubMed - indexed for MEDLINE]

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