Regulation and functions of inflammasome-mediated cytokines in Helicobacter pylori infection

Publication date: Available online 6 July 2017
Source:Microbes and Infection
Author(s): Le Son Tran, Michelle Chonwerawong, Richard L. Ferrero
Persistent stomach infection with Helicobacter pylori causes chronic mucosal inflammation (gastritis), which is widely recognized as an essential precursor to gastric cancer. The IL-1 interleukin family cytokines IL-1β and IL-18 have emerged as central mediators of mucosal inflammation. Here, we review the regulation and function of these cytokines in H. pylori-induced inflammation and carcinogenesis.



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