Σφακιανάκης Αλέξανδρος
ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5 Άγιος Νικόλαος
Κρήτη 72100
00302841026182
00306932607174
alsfakia@gmail.com

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! # Ola via Alexandros G.Sfakianakis on Inoreader

Η λίστα ιστολογίων μου

Τρίτη 8 Αυγούστου 2017

Allergic sensitization to laboratory animals is more associated with asthma, rhinitis and skin symptoms than sensitization to common allergens

Summary

Background

Workers exposed to laboratory animals have a high risk of developing laboratory animal allergy (LAA). Atopy seems to be the main risk factor for LAA. We hypothesized that occupational sensitization is a better predictor for the development of asthma, rhinitis and bronchial hyperresponsiveness than common sensitization.

Objective

To investigate the association between occupational sensitization to laboratory animals and clinical outcomes.

Methods

This was a cross-sectional study performed at two universities on students and employees dealing with small rodents. The subjects were allocated in groups: non-sensitized, common sensitization or occupational sensitization, according to the results of the skin prick test (SPT). All subjects answered a questionnaire about animal exposures, symptoms, allergic diseases, and underwent spirometry and bronchial challenge test with mannitol. Multivariate analysis was performed by using Poisson regression to estimate the prevalence ratio (PR).

Results

Data from 453 volunteers were analyzed. Non-sensitized group comprised 237 subjects; common sensitization group, 142 subjects; and occupational sensitization group, 74 subjects. Occupational sensitization was associated with greater risk for all outcomes studied. When the common sensitization group was reference, skin symptoms had PR of 1.36; 95% confidence interval (CI): 1.01-1.85; wheezing had PR of 1.75; CI 95%: 1.21-2.53; rhinitis had PR of 1.25; 95%: 1.11-1.40; nocturnal dyspnea had PR of 2.40; 95% CI: 1.31-4.40; bronchial hyperresponsiveness had PR of 2.47; 95% CI: 1.50-4.09; and confirmed asthma had PR of 2.65; 95% CI: 1.45-4.85. In addition, the overlap of asthma, rhinitis and skin symptoms in a same subject was significantly more prevalent in the occupational sensitization group, 16.2% versus 4.9% in the common sensitization group.

Conclusion and Clinical Relevance

Occupational sensitization is associated with allergic symptoms and respiratory diseases. SPT with occupational allergens along with other parameters may contribute to detection of risk for allergic and respiratory diseases associated with exposure to laboratory animals.

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