Publication date: October 2017
Source:Biomedicine & Pharmacotherapy, Volume 94
Author(s): Gangqiang Ding, Wei Li, Junping Liu, Yanli Zeng, Chongshan Mao, Yi Kang, Jia Shang
BackgroundGHET1 is one of tumor-related lncRNAs. We aimed to explore the functional involvement of GHET1 in hepatocellular carcinoma (HCC).MethodsIn this study, HCC tissues and the paired normal tissues were collected for the detection of target molecules. The expression level of target molecules in HCC tissues or cell lines was determined by qRT-PCR and western blot, respectively. The expression of endogenous GHET1 and ATF1 was modulated by using cell transfection. RNA pull down assay was performed to examine the interaction between GHET1 and ATF1. ChIP assay was conducted to determine the H3K27Ac acetylation of GHET1 promoter.ResultsH3K27 acetylation activated-GHET1 was upregulated in HCC tissues and cell lines. Moreover, GHET1 silencing could inhibit the proliferation, migration, invasion and EMT of HCC cells in vitro. GHET1 could regulate the expression of ATF1 mRNA and protein; RNA pull-down assays supported that GHET1 could bind to ATF1 protein. Furthermore, overexpression of ATF1 almost completely reversed the GHET1 knockdown mediated inhibition on the proliferation, migration, invasion and EMT of HCC cells.ConclusionLncRNA GHET1 was intimately involved in the occurrence and development of HCC through regulating ATF1.
http://ift.tt/2vq8mZQ
Σφακιανάκης Αλέξανδρος
ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5 Άγιος Νικόλαος
Κρήτη 72100
00302841026182
00306932607174
alsfakia@gmail.com
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! # Ola via Alexandros G.Sfakianakis on Inoreader
Η λίστα ιστολογίων μου
Τρίτη 1 Αυγούστου 2017
LncRNA GHET1 activated by H3K27 acetylation promotes cell tumorigenesis through regulating ATF1 in hepatocellular carcinoma
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- SCIAMACHY observed changes in the column mixing ra...
- Multi year aerosol characterization in the tropica...
- Urban air pollution and health risks of parent and...
- Neural Evidence for Non-conscious Working Memory
- Transcription Factors Sp8 and Sp9 Coordinately Reg...
- Efficacy of a novel swallowing exercise program fo...
- Symptom burden and patient characteristics: Associ...
- Efficacy of a novel swallowing exercise program fo...
- Symptom burden and patient characteristics: Associ...
- The Mediator Complex: At the Nexus of RNA Polymera...
- College student with actigraphy performed during f...
- Sleep Phenotypes in Infants and Toddlers with Neur...
- Reduced P300 amplitude during a visuospatial atten...
- Correlation Between the Epworth Sleepiness Scale a...
- Relapse insomnia increases greater risk of anxiety...
- A preliminary examination of gut microbiota, sleep...
- A comparison of the tongue-in-groove and columella...
- CONTENTS 1
- CONTENTS 2
- Cytological and histological changes in the urothe...
- Thyroid Transcription Factor-1 promotes lymph node...
- Exploration of the pathways and interaction networ...
- Evaluation of expression of genes CADM1, TWIST1 an...
- Optical Loupes: A Useful Tool for the Oncall Otorh...
- Optical Loupes: A Useful Tool for the Oncall Otorh...
- Botulinum Toxin Injections Into the Lateral Cricoa...
- Optical Loupes: A Useful Tool for the Oncall Otorh...
- Optical Loupes: A Useful Tool for the Oncall Otorh...
- The impact of onabotulinumtoxinA on severe headach...
- Evaluation of the budding and depth of invasion (B...
- Desensitization to a whole egg by rush oral immuno...
- Cordyceps Sinensis: Anti-fibrotic and inflammatory...
- Biology and management of Avena fatua and Avena lu...
- Is myometrial inflammation a cause or a consequenc...
- Anti-inflammatory effects of exercise training in ...
- Lead-free (Ba,Ca)(Ti,Zr)O3 ceramics within the pol...
- Manufacturing of FeCoCrNiCux medium-entropy alloy ...
- Enhanced strength and ductility of bulk CoCrFeMnNi...
- Duplex stainless steel fabricated by selective las...
- Analyses of a Mutant Foxp3 Allele Reveal BATF as a...
- An antigen-specific semi-therapeutic treatment wit...
- Non-proinflammatory and responsive nanoplatforms f...
- Advance Directives, Hospitalization, and Survival ...
- A Phase II Study with Lead‐In Safety Cohort of 5‐F...
- Comparative efficacy of pharmacological and non-ph...
- Daphnoretin modulates differentiation and maturati...
- Inside front cover
- Naturally occurring immunomodulators with antitumo...
- Characterization and evaluation of nanoencapsulate...
- Reevaluating the Sensory Account of Visual Working...
- Retropharyngeal abscess as a result of hyaluronic ...
- Histopathology of tympanic membranes from patients...
- Tmj total reconstruction with stock and custom mad...
- Vitiligo: Mechanistic Insights Lead to Novel Treat...
- Expansion of cytotoxic CD56bright NK cells during ...
- Expansion of cytotoxic CD56bright NK cells during ...
- Vitiligo: Mechanistic Insights Lead to Novel Treat...
- Retropharyngeal abscess as a result of hyaluronic ...
- Retropharyngeal abscess as a result of hyaluronic ...
- Increasing positive attitudes toward individuals w...
- Increased malignancy incidence in IgE deficient pa...
- Hypogammaglobulinemia E in 216 adults with IgG sub...
- Zika virus infection as a trigger of atopic dermat...
- Increased malignancy incidence in IgE deficient pa...
- Bronchial thermoplasty induces immunomodulation wi...
- Zika virus infection as a trigger of atopic dermat...
- Guidelines for Drinking-Water Quality: Fourth Edit...
- Interventions to Prevent Age-Related Cognitive Dec...
- The black rock series supported SCR catalyst for N...
- PRP Popular for Alopecia Despite Lack of Robust Ev...
- Determinants of Implementation of Isolation Precau...
- Reflector-guided breast tumor localization versus ...
- Screening performance for callosal agenesis in pre...
- Vaginal tumor–vesical fistula detected by dynamic ...
- Pt-decorated zinc oxide nanorod arrays with graphi...
- Perpendicular magnetic anisotropy in ZnMnS ultra-t...
- Anticancer Agents; +345 new citations
- Arthroconidia in Lung Tissue: An Unusual Histopath...
- Bilateral pheochromocytoma with ganglioneuroma com...
- Impedance cardiography in healthy children and chi...
- Executive Functions Impact the Relation Between Re...
- Noise Equally Degrades Central Auditory Processing...
- Carbon dots based photoelectrochemical sensors for...
- Development and application of a novel fluorescent...
- Integrating fluorescent molecularly imprinted poly...
- Mkit: A cell migration assay based on microfluidic...
- The Role of Simulation in Microsurgical Training
- Neurogenic Orofacial Weakness and Speech in Adults...
- In vitro genotoxicity of asbestos substitutes indu...
- Chemical properties of dissolved organic matter de...
- Expression of intelectin-1 in bronchial epithelial...
- Expression of intelectin-1 in bronchial epithelial...
- Bilateral pheochromocytoma with ganglioneuroma com...
- Dendritic cell recruitment and activation in autoi...
- Holding Onto Youth
- Burning Fat and Building Bone by FSH Blockade
- What’s So Special about FGF19—Unique Effects Repor...
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