Effect of the inclusion nanocomplex formed of titanium tetrafluoride and β-Cyclodextrin on enamel remineralization

Thiago Isidro Vieira, Camila Nassur, Adílis Kalina Alexandria, Luciana Pomarico, Valeria Pereira Sousa, Lúcio Mendes Cabral, Ana Maria G Valença, Lucianne Cople Maia

Journal of Pharmacy And Bioallied Sciences 2017 9(3):201-207

Objective: Titanium tetrafluoride (TiF4) is a topical agent used in the control of dental caries; however, it is highly acidic. To minimize this effect, cyclodextrins (CDs) are used. This study evaluated the in vitro potential of TiF4and β-CD on remineralization. Methods: Forty bovine enamel blocks were selected by microhardness and randomly assigned to four groups (n = 10 per group): control (distilled and deionized water), 1% β-CD solution, 1% TiF4solution, and TiF4: β-CD solution. The blocks were subjected to a pH cycling regimen for 8 days. After that, samples were evaluated by cross-sectional microhardness (CSMH), scanning electron microscopy (SEM), and energy dispersive spectrometry (EDS). Data were assessed for normality and analyzed using ANOVA and Tukey's tests (α = 0.05). Results: Regarding CSMH, TiF4: β-CD was statistically superior to the control (P = 0.033), β-CD (P = 0.022), and TiF4(P = 0.006). SEM photomicrography revealed the titanium dioxide coating on slabs treated with TiF4and TiF4: β-CD. EDS assessment demonstrated the presence of titanium on the surface of slabs treated with TiF4and TiF4: β-CD. Conclusion: The solution containing the inclusion nanocomplex formed of TiF4and β-CD was able to reharden the enamel subsurface.

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