Heart dose associated with overall survival in locally advanced NSCLC patients treated with hypofractionated chemoradiotherapy

Publication date: Available online 19 September 2017
Source:Radiotherapy and Oncology
Author(s): Barbara Stam, Erik van der Bijl, Judi van Diessen, Maddalena M.G. Rossi, Angela Tijhuis, José S.A. Belderbos, Eugène Damen, Jan-Jakob Sonke
Association of heart dose and overall survival was investigated in a cohort including 469 locally-advanced NSCLC patients receiving daily low-dose hypofractionated chemo-radiotherapy. Significant associations were found over a range of dose parameters. Multivariate analysis showed significant associations of heart_V2Gy:HR=1.007%⁻¹ (95% CI:1.002–1.013; p=0.006), age:HR=1.026year⁻¹ (1.011–1.042; p=0.001) and GTV volume:HR=1.001cc⁻¹ (1.000–1.002; p=0.006) with overall survival.



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