Σφακιανάκης Αλέξανδρος
ΩτοΡινοΛαρυγγολόγος
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Πέμπτη 28 Σεπτεμβρίου 2017

Interplay of upper and lower motor neuron degeneration in amyotrophic lateral sclerosis

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Publication date: November 2017
Source:Clinical Neurophysiology, Volume 128, Issue 11
Author(s): Mamede de Carvalho, Artiom Poliakov, Cristiano Tavares, Michael Swash
ObjectiveWe studied motor unit recruitment to test a new method to identify motor unit firing rate (FR) variability.MethodsWe studied 68 ALS patients, with and without upper neuron signs (UMN) in lower limbs, 24 patients with primary lateral sclerosis (PLS), 13 patients with spinal cord lesion and 39 normal subjects. All recordings were made from tibialis anterior muscles of normal strength. Subjects performed a very slight contraction in order to activate 2 motor units in each recording. 5–7 motor unit pairs were recorded in each subject. Mean consecutive differences (MCD) were calculated for each pair of potentials. The mean MCD for each muscle was estimated as the mean from the total number of pairs recorded. Ap value<0.01 was accepted as significant.ResultsMCD of FR frequency was less in the subjects with spinal cord lesion and PLS. In addition, the FR frequency of the 1st motor unit in a pair of units was markedly reduced in PLS, and in subjects with spinal cord lesions.ConclusionThese results support a lower threshold and reduced FR fluctuation in spinal motor neurons of spastic patients.SignificanceThis method can be developed for detection of UMN lesions.



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