[Research advances in the protective effect of all-trans retinoic acid against podocyte injury].

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[Research advances in the protective effect of all-trans retinoic acid against podocyte injury].

Zhongguo Dang Dai Er Ke Za Zhi. 2017 Jun;19(6):719-723

Authors: Chen XP, Qin YH

Abstract
All-trans retinoic acid (ATRA) is a vitamin A derivative and plays an important role in the regulation of cell aggregation, differentiation, apoptosis, proliferation, and inflammatory response. In recent years, some progress has been made in the role of ATRA in renal diseases, especially its protective effect on podocytes. This article reviews the research advances in podocyte injury, characteristics of ATRA, podocyte differentiation and regeneration induced by ATRA, and the protective effect of ATRA against proliferation, deposition of fibers, and apoptosis.

PMID: 28606243 [PubMed - indexed for MEDLINE]

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