OR031 Preventive effect of subcutaneous C1 inhibitor in patients with very frequent attacks of hereditary angioedema

Prophylaxis with subcutaneous C1 inhibitor (C1-INH [SC]) provided excellent preventive effect against hereditary angioedema (HAE) attacks in the COMPACT study (NEJM 2017;376:1131-40) in type I/II HAE patients with attack frequency of ≥4 attacks/2 consecutive months. The prophylactic effect of C1-INH (SC) in severely affected patients (≥4 attacks/month) is not known, hence it was of interest to analyze this subgroup.

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