Σφακιανάκης Αλέξανδρος
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Τετάρτη 4 Οκτωβρίου 2017

Spontaneous brain oscillations as neural fingerprints of working memory capacities: A resting-state MEG study

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Publication date: Available online 3 October 2017
Source:Cortex
Author(s): Victor Oswald, Younes Zerouali, Aubrée Boulet-Craig, Maja Krajinovic, Caroline Laverdière, Daniel Sinnett, Pierre Jolicoeur, Sarah Lippé, Karim Jerbi, Philippe Robaey
Short-term storage and mental information manipulation capacities in the human brain are key to healthy cognition. These brain processes collectively known as working memory (WM) are associated with modulations of rhythmic brain activity across multiple brain areas and frequencies. Yet, it is not clear whether –and, if so, how-intrinsic resting-state neuronal oscillations are related to individual WM capacities, as measured by standard neuropsychological tests. We addressed this question by probing the correlation between resting-state brain activity, recorded with magnetoencephalography (MEG), and verbal and visuo-spatial WM indices obtained from the standardized Wechsler Adult Intelligence Scale (WAIS-IV) and the Wechsler Memory Scale (WMS-IV). To this end, 5-min eyes-open resting-state MEG data were acquired in 28 healthy participants. Source-reconstructed spectral power estimates were then computed in standard frequency bands and their correlation with neuropsychological indices across individuals was assessed using Pearson correlation and cluster-level statistics. We found statistically significant positive correlations between spectral amplitudes measured at rest and standardized scores on both verbal and visuo-spatial working memory performance. The correlation clusters primarily involved key medial and dorsolateral components within the parietal and prefrontal regions. In addition, while the correlation in some clusters was frequency selective (e.g. alpha-band oscillations), other areas showed correlations with WM across a wide range of frequencies reflecting a broadband effect. These results provide the first evidence for a positive correlation between neuromagnetic signals measured at rest and WM performance separately assessed by standardized neuropsychological tests. Our results advance our understanding of the link between WM capacities and intrinsic oscillatory dynamics networks. They also suggest that individual differences in baseline spectral power might need to be taken into account when probing differences in brain responses during the execution of WM tasks.



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