Short term ibrutinib therapy suppresses skin test responses and eliminates IgE-mediated basophil activation in adults with peanut or tree nut allergy

Publication date: Available online 31 January 2018
Source:Journal of Allergy and Clinical Immunology
Author(s): Melanie C. Dispenza, Jacqueline A. Pongracic, Anne Marie Singh, Bruce S. Bochner

Teaser

Two doses of ibrutinib significantly reduced skin prick test area and anti-IgE-induced basophil activation responses in peanut and tree nut allergic adults. Ibrutinib or other BTK inhibitors could potentially be used to prevent anaphylaxis.


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