Concurrent IgE-mediated NMBA-allergy in systemic mastocytosis

Mastocytosis is a rare clinical condition characterized by an abnormal increase in tissue mast cells, which can be limited to the skin (cutaneous mastocytosis) or infiltrate the bone marrow and other organs with or without skin involvement (systemic mastocytosis). Systemic mastocytosis (SM) is reported primarily in adulthood, where indolent SM is the most common form. We report an unusual case consistent with IgE-mediated neuromuscular blocking agent (NMBA) allergy evidenced in a patient with previously unsuspected mastocytosis.

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