Botulinum Toxin-A Dosing Trends for Adductor Spasmodic Dysphonia at a Single Institution Over 10 Years.

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Botulinum Toxin-A Dosing Trends for Adductor Spasmodic Dysphonia at a Single Institution Over 10 Years.

J Voice. 2017 May;31(3):363-365

Authors: Bradley JP, Barrow EM, Hapner ER, Klein AM, Johns MM

Abstract
OBJECTIVES: This study aimed to identify the changes in dosing of botulinum toxin-A for adductor spasmodic dysphonia (ADSD) over a prolonged period.
STUDY DESIGN: This is a retrospective chart review.
METHODS: One hundred thirteen subjects treated for ADSD from 2003 to 2013 were identified from a clinical database. Subject age, gender, and total injection dose amount were all recorded for all subjects who had at least 10 injections.
RESULTS: Fifty-four subjects met criteria for inclusion. There were no age or gender differences in the starting dose for subjects. Dosing decreased significantly compared with the second dose (5.05 ± 1.623 Units), by the sixth dose (4.26 ± 1.698 Units), and continued through the 10th dose (4.08 ± 2.019 Units) (P < 0.005 for all).
CONCLUSIONS: Botulinum toxin-A dosing for ADSD decreases consistently over subsequent injections after the initial two dose titrations.

PMID: 27839987 [PubMed - indexed for MEDLINE]

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