Diagnostic performance of PET/MR in the evaluation of active inflammation in Crohn disease.

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Diagnostic performance of PET/MR in the evaluation of active inflammation in Crohn disease.

Am J Nucl Med Mol Imaging. 2018;8(1):62-69

Authors: Catalano OA, Wu V, Mahmood U, Signore A, Vangel M, Soricelli A, Salvatore M, Gervais D, Rosen BR

Abstract
This study investigates the performance of PET/MR versus each sub-modality alone in the assessment of active inflammation in patients with Crohn disease, when compared to surgery as standard of reference. Sensitivity for detecting active inflammation was 91.5% for PET, 80% for MR, and 88% for PET/MR. Specificity for active inflammation was 74% for PET, 87% for MR, and 93% for PET/MR. Diagnostic accuracy was 84% for PET, 83% for MR, and 91% for PET/MR. In conclusion, PET/MR is significantly more accurate than either sub-modality alone and more specific than PET alone in the detection of active inflammation in patients with Crohn disease.

PMID: 29531862 [PubMed]

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