Σφακιανάκης Αλέξανδρος
ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5 Άγιος Νικόλαος
Κρήτη 72100
00302841026182
00306932607174
alsfakia@gmail.com

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Δευτέρα 12 Μαρτίου 2018

Laparoscopic surgery in the treatment of stage I adult granulosa cells tumors of the ovary: results from the MITO-9 study

Publication date: Available online 10 March 2018
Source:European Journal of Surgical Oncology
Author(s): A. Bergamini, G. Ferrandina, M. Candiani, G. Cormio, G. Giorda, R. Lauria, A.M. Perrone, G. Scarfone, E. Breda, A. Savarese, L. Frigerio, A. Gadducci, F. Mascilini, F. Maneschi, C. Cassani, C. Marchetti, S.C. Cecere, N. Biglia, U. De Giorgi, F. Raspagliesi, D. Lorusso, G. Mangili
ObjectiveSurgery represents the mainstay of treatment of stage I adult type granulosa cell tumors of the ovary (AGCTs). Because of the rarity and indolent course of the disease, no prospective trials are available. Open surgery has long been considered the traditional approach; oncological safety of laparoscopy is only supported by small series or case reports. The aim of this study was to compare the oncological outcomes between laparoscopic and open surgery in stage I AGCTs treated within the MITO (Multicenter Italian Trials in Ovarian cancer) Group.Methodsdata from patients with stage I AGCTs were retrospectively collected. Clinicopathological features were evaluated for association with relapse and death. Survival curves were calculated using the Kaplan-Meier method and compared with the log-rank test. The role of clinicopathological variables as prognostic factors for survival was evaluated using Cox's regression model.Results223 patients were identified. Stage 1A, 1B and 1C were 61.5%, 1.3% and 29.6% respectively. 7.6% were apparently stage I. Surgical approach was laparoscopic for 93 patients (41.7%) and open for 130 (58.3%). 5-years DFS was 84% and 82%, 10-years DFS was 68% and 64% for the laparoscopic and open-group(p=0.6).5-years OS was 100% and 99%, 10 years OS was 98% and 97% for the laparoscopic and open-surgery group(p=0.8). At multivariate analyses stage IC, incomplete staging, site of primary surgery retained significant prognostic value.Conclusionthe present study suggests that surgical route does not affect the oncological safety of patients with stage I AGCTs, with comparable outcomes between laparoscopic and open approach.



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